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Drivers of excessive ROS production along with mitochondrial and ER oxidative stress are WAT chronic inflammation, insulin resistance in obesity and advanced glycation end products (AGEs) produced in T2D [140,143,144]

Luciferase reporter gene assay STAT3 transcription was measured using pGL4.47[luc2P/SIE/Hygro] (Promega, Madison, WI, USA) according to the manufacturers instructions

The peer-reviewed published research was conducted at Penn State University and demonstrated a 28% increase in intracellular glutathione levels in just 2 weeks

JAMA (2017) 318(15):146070